L-Stepholidine

Catalog Number	ACM16562133-1
CAS Number	16562-13-3
Structure
Description	L-Stepholidine is a natural compound that has been shown to have synergistic effects with anti-cancer compounds such as 5-Fluorouracil. L-Stepholidine also has a matrix effect on tumor cells, which is thought to be due to its ability to inhibit the enzyme activity of matrix metalloproteinases. This inhibition may lead to the inhibition of metastasis and tumor growth. L-Stepholidine also has an effect on locomotor activity in rats and on voltage-dependent calcium channels. It has been shown to bind to dopamine receptors in humans, and this binding can lead to structural changes in the receptor that are associated with Parkinson's disease.
Synonyms	3,9-Dimethoxy-13a-alpha-berbine-2,10-diol
Molecular Weight	327.37 g/mol
Molecular Formula	C19H21NO4
Canonical SMILES	COC1=C(C=C2[C@@H]3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O
InChI	InChI=1S/C19H21NO4/c1-23-18-8-12-5-6-20-10-14-11(3-4-16(21)19(14)24-2)7-15(20)13(12)9-17(18)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m0/s1
InChI Key	JKPISQIIWUONPB-HNNXBMFYSA-N
Melting Point	120-122 °C
Purity	90%+
Appearance	White to off-white crystalline powder
Storage	store at 10℃-25℃
Complexity	447
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	1
Exact Mass	327.14705815
Harmonized Tariff Code	Switzerland: 29072920 - USA: 2907299000 - Slovakia: 2907290025 - UK: 2907290000 - China: 2907290090
Heavy Atom Count	24
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	2
Isomeric SMILES	COC1=C(C=C2[C@@H]3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O
MDL Number	MFCD00211195
Monoisotopic Mass	327.14705815
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	62.2 Ų

Custom Q&A

What is the full chemical name of L-SPD?

The full chemical name of L-SPD is 3,9-dimethoxy-13a-alpha-berbine-2,10-diol.

What is the molecular formula of L-SPD?

The molecular formula of L-SPD is C19H21NO4.

What is the melting point of L-SPD?

The melting point of L-SPD is 120-122°C.

What is the boiling point of L-SPD?

The boiling point of L-SPD is predicted to be 524.0±50.0°C.

What is the storage temperature recommended for L-SPD?

L-SPD should be stored at -20°C.

What is the solubility of L-SPD?

L-SPD is soluble in DMSO.

What is the primary usage of L-SPD?

L-SPD is a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, used for preventing or treating neural diseases.

What are the neural diseases that L-SPD can be used to treat?

L-SPD can be used to treat parkinsonism, schizophrenia, and dyskinesia produced by L-DOPA or medicine to treat schizophrenia.

What is the target of L-SPD in the body?

The target of L-SPD is the dopamine receptor and 5-HT receptor.

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