Meleagrin

Catalog Number	ACM71751774-1
CAS Number	71751-77-4
Description	Meleagrin is a natural antimicrobial peptide that has been shown to have significant cytotoxicity against hl-60 and k562 human leukemia cells. It also inhibits the growth of wild-type bacteria, such as Escherichia coli and Enterococcus faecalis, by binding to their ribosomes. Meleagrin also has potent antitumor activity against various cancer cell lines in vitro and in vivo. It binds to basic proteins in the bacterial cell wall, which are responsible for maintaining its shape. Furthermore, meleagrin can be used to treat skin infections caused by Staphylococcus aureus because it binds to the enzyme penicillin-binding protein 2a (PBP2a) and prevents formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division.
Canonical SMILES	CC(C)(C=C)[C@@]12C=C(C(=O)N\3[C@]1(NC(=O)/C3=C\C4=CN=CN4)N(C5=CC=CC=C25)OC)O

Custom Q&A

What is the chemical formula of Meleagrin?

The chemical formula of Meleagrin is C23H23N5O4.

What is the molecular weight of Meleagrin?

The molecular weight of Meleagrin is 433.46.

What is the storage temperature recommended for Meleagrin?

The storage temperature recommended for Meleagrin is -20°C.

What is the solubility of Meleagrin?

Meleagrin is soluble in DMSO (up to 10 mg/ml).

What is the color of Meleagrin?

Meleagrin is in the form of a yellow oil with a tan color.

What is the primary usage of Meleagrin?

Meleagrin is an alkaloid with antitumor and antibiotic activity, isolated from Penicillium.

What does Meleagrin inhibit in bacterial cells?

Meleagrin inhibits the bacterial enoyl-acyl carrier protein reductase (Fabl).

How is Meleagrin synthesized in nature?

Meleagrin is biosynthesized through the roquefortine branched biosynthetic pathway.

What is the storage condition recommended for solutions of Meleagrin in DMSO?

Solutions of Meleagrin in DMSO may be stored at -20°C for up to 3 months.

What is the potential impact of Meleagrin treatment on different types of cells?

Meleagrin has been shown to inhibit the growth of certain bacterial strains and exhibit ATP-competitive c-MET inhibitory activity in breast cancer cell lines.

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