Nitidine

Catalog Number	ACM6872577-1
CAS Number	6872-57-7
Synonyms	8,9-Dimethoxy-2,3-methylenedioxy-5-methylbenzo[c]phenanthridin-5-ium
Molecular Weight	348.4
InChI	InChI=1S/C21H18NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-10H,11H2,1-3H3/q+1
InChI Key	KKMPSGJPCCJYRV-UHFFFAOYSA-N
Melting Point	281-283 °C
Purity	95%+
Complexity	516
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	348.12358306
Heavy Atom Count	26
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	0
Monoisotopic Mass	348.12358306
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	40.8 Ų

Case Study

Evaluation of Antimalarial Activity of Nitidine

Bouquet, Jérome, et al. Malaria Journal, 2012, 11, 1-8.

Nitidine is considered the main active ingredient in several traditional antimalarial drugs. This work evaluated the antimalarial activity of nitidine, indicating that nitidine is considered a potential antimalarial lead compound.
Assessment methods and conclusions
· The effectiveness of nitidine as an anti-malarial agent was assessed in vitro on both chloroquine-sensitive and chloroquine-resistant strains. Subsequently, the selectivity index of nitidine in comparison to cancerous and non-cancerous cell lines was calculated. In vivo experiments were then conducted following the Peter's test methodology over a four-day period. To understand how nitidine operates, its impact on the parasite's cell cycle was investigated, and its localization within the parasite was determined utilizing confocal microscopy.
· Nitidine exhibited consistent in vitro efficacy against both chloroquine-sensitive and resistant strains and displayed a favorable selectivity index (> 10) when assessed against non-cancerous cell lines. Although its in vivo effectiveness was moderate, there were no indications of acute toxicity observed during the treatment. Analysis of nitidine's impact on the parasite's cell cycle revealed that it did not disrupt DNA replication, which aligned with the finding that nitidine was predominantly located in the cytoplasm rather than the nucleus of the parasite. Furthermore, nitidine formed a 1-1 complex with haem in vitro and effectively hindered the formation of β-haematin with comparable potency to chloroquine.

Custom Q&A

What is the chemical formula for Nitidine?

The chemical formula for Nitidine is C21H18NO4+.

What is the molecular weight of Nitidine?

The molecular weight of Nitidine is 348.37 g/mol.

What is the melting point of Nitidine?

The melting point of Nitidine is 281-283℃.

What are some synonyms for Nitidine?

Some synonyms for Nitidine include Nididine and NSC 146397.

What is the CAS number for Nitidine?

The CAS number for Nitidine is 6872-57-7.

In what product category does Nitidine fall under?

Nitidine falls under the category of Active Pharmaceutical Ingredients.

What is the chemical definition of Nitidine according to ChEBI?

According to ChEBI, Nitidine is a member of phenanthridines.

What is the full chemical name of Nitidine?

The full chemical name of Nitidine is 2,3-(Epoxymethanoxy)-5-methyl-8,9-dimethoxybenzo[c]phenanthridine-5-ium.

What is the common use of Nitidine?

Nitidine is commonly used as an Active Pharmaceutical Ingredient.

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