Nitidine chloride

Catalog Number	ACM13063042
CAS Number	13063-04-2
Description	Nitidine chloride is a potent inducer of energy metabolism and has been shown to stimulate the growth of cells in tissue culture. It is also active against cancer cells, and has been shown to decrease cell proliferation, induce apoptosis, and inhibit angiogenesis. Nitidine chloride has been shown to be an inhibitor of protein synthesis by binding to the polymerase chain reaction (PCR) enzyme. Nitidine chloride can also affect cell nuclei by inhibiting DNA replication. The mechanism of action for nitidine chloride is not fully understood but may be due to its ability to bind with DNA or RNA in cells. This binding inhibits transcription and translation processes, leading to inhibition of protein synthesis and cell death. Nitidine chloride is found naturally in plants such as Ginkgo biloba and Acorus calamus. The compound can be synthesized from chloroacetamide, a natural compound that is produced by bacteria such as Corynebacterium glutamicum.
Molecular Weight	383.82 g/mol
Molecular Formula	C21H18ClNO4
Canonical SMILES	C[N+]1=CC2=CC(=C(C=C2C3=C1C4=CC5=C(C=C4C=C3)OCO5)OC)OC.[Cl-]
Storage	store at 10℃-25℃, close container well
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939799090 - China: 2939799099
MDL Number	MFCD01659688

Custom Q&A

What is the product name of the chemical compound with CAS number 13063-04-2?

The product name is Nitidine chloride.

What are some synonyms of Nitidine chloride?

Some synonyms of Nitidine chloride are Angolinine, NITIDINE, and NITIDINE CHLORIDE.

What is the molecular formula of Nitidine chloride?

The molecular formula of Nitidine chloride is C21H18NO4+.

What is the melting point of Nitidine chloride?

The melting point of Nitidine chloride is 283-286 °C.

In what form is Nitidine chloride usually isolated?

Nitidine chloride is normally isolated as the chloride.

What is the primary source of Nitidine chloride?

Nitidine chloride occurs primarily in Zanthoxylum nitidum (Lam.) DC and several species of Fagara.

What is the role of Nitidine chloride in inhibiting hepatic cancer growth?

Nitidine chloride shows the ability to inhibit hepatic cancer growth through modulation of signaling pathways.

What toxicological information is available about Nitidine chloride?

The LD50 value for Nitidine chloride in mice via intraperitoneal route is 98980ug/kg.

How is Nitidine chloride prepared?

Nitidine chloride can be prepared by a reaction with triphosgene in acetonitrile followed by recrystallization from ethanol/diethyl ether.

What are some of the pathways involved in the anti-cancer activity of Nitidine chloride?

The anti-cancer activity of Nitidine chloride likely involves inhibiting topoisomerase I and II, inducing cell apoptosis, and suppressing various signaling pathways like c-Src/FAK and Janus kinase 2/STAT3.

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