Palmatine

Catalog Number	ACM3486677-1
CAS Number	3486-67-7
Structure
Description	Palmatine is a natural compound with inhibitory properties that has been shown to be active against various infectious diseases in vitro. Palmatine inhibits the activity of recombinant cytochrome P450 enzymes, which are involved in the metabolism of xenobiotics and endogenous substrates. The compound also binds to bacterial DNA and inhibits RNA synthesis, leading to cell death.
Synonyms	5,6-Dihydro-2,3,9,10-tetramethoxydibenzo[a,g]quinolizinium
IUPAC Name	2,3,9,10-Tetramethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium
Molecular Weight	352.4 g/mol
Molecular Formula	C21H22NO4
Canonical SMILES	COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)OC)OC
InChI	InChI=1S/C21H22NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,9-12H,7-8H2,1-4H3/q+1
InChI Key	QUCQEUCGKKTEBI-UHFFFAOYSA-N
Melting Point	205 °C
Purity	98%
Appearance	Powder
Storage	store at 2℃-8℃
Complexity	475
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	352.15488318
Harmonized Tariff Code	Switzerland: 29334900 - USA: 2933492600 - Slovakia: 2933490000 - UK: 2933499000 - China: 2933490099
Heavy Atom Count	26
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	0
MDL Number	MFCD00221758
Monoisotopic Mass	352.15488318
PhysicalState	Powder
Rotatable Bond Count	4
Topological Polar Surface Area	40.8 Ų

Custom Q&A

What is the melting point of Palmatine?

The melting point of Palmatine is 205°C.

In what form is Palmatine typically found?

Palmatine is typically found in powder form.

What is the LogP of Palmatine estimated to be?

The LogP of Palmatine is estimated to be -1.120.

What is the LD50 of Palmatine in mice when administered subcutaneously?

The LD50 of Palmatine in mice when administered subcutaneously is 135mg/kg.

What is the main pharmacological effect of Palmatine?

Palmatine is known for its detoxification and antimicrobial effects.

Where is Palmatine commonly found in nature?

Palmatine is frequently found in plants belonging to the Rhoeadales order, such as Cop tis japonica and Berberis vulgaris.

How is Palmatine useful in clinical treatment?

Palmatine is used in the treatment of various infections, gynecological inflammations, and respiratory tract infections.

What is the main source of natural Palmatine?

Natural Palmatine is mainly obtained from the extraction of dry rattan of the plant Huangteng.

What are some of the safety considerations associated with Palmatine?

Palmatine should be stored under inert gas at 2-8°C, and it has a toxicity profile in mice.

How is Palmatine typically extracted from its natural source?

Palmatine is typically extracted using acid water decoction and salting out with NaCl to obtain high-quality and high-purity Palmatine.

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