Procaine

Catalog Number	ACM59461
CAS Number	59-46-1
Synonyms	Vitamin H3
IUPAC Name	2-(Diethylamino)ethyl 4-aminobenzoate
Molecular Weight	236.31
Molecular Formula	C13H20N2O2
Canonical SMILES	CCN(CC)CCOC(=O)C1=CC=C(C=C1)N
InChI	InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3
InChI Key	MFDFERRIHVXMIY-UHFFFAOYSA-N
Boiling Point	378.78 °C
Melting Point	61 °C
Flash Point	179.8 °C
Purity	99%
Density	1.0604 g/cm³
Solubility	Soluble in ethanol, ethyl ether, benzene
Appearance	White to off-white solid
Storage	Keep in dark place, sealed in dry, room temperature
Complexity	222
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	0
Exact Mass	236.152477885
Heavy Atom Count	17
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	1
Monoisotopic Mass	236.152477885
PhysicalState	Powder
Rotatable Bond Count	7
Topological Polar Surface Area	55.6 Ų

Custom Q&A

What is the molecular formula of Procaine?

The molecular formula of Procaine is C13H20N2O2.

What is the melting point of Procaine?

The melting point of Procaine is 61°C.

What are the chemical properties of Procaine?

Procaine is a local anesthetic with a para-amino function.

How is Procaine usually referred to?

The hydrochloride salt of Procaine is generally referred to as procaine.

What are the main uses of Procaine?

Procaine is mainly used in dental or medical procedures requiring infiltration anesthesia, peripheral block, or spinal block.

What is the mechanism of action of Procaine?

Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves.

How is Procaine metabolized in the body?

Procaine is very quickly metabolized in the plasma by cholinesterases and in the liver via ester hydrolysis by a pseudocholinesterase.

What are the side effects of taking Procaine orally?

When taken by mouth, Procaine can cause side effects including heartburn, migraines, and a condition called systemic lupus erythematosus.

How is Procaine synthesized experimentally?

Procaine is synthesized by adding p-nitrobenzoic acid, dimethylbenzene, and Diethylaminoethanol in a reaction flask, followed by hydrogenation and filtration.

How is Procaine purified?

Procaine can be purified by crystallizing as the dihydrate from aqueous EtOH or as the anhydrous material from pet ether or diethyl ether.

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