Protopine hydrochloride

Catalog Number	ACM6164472-2
CAS Number	6164-47-2
Synonyms	Protopine HCl
IUPAC Name	15-Methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.04,12.06,10.018,22]tetracosa-1(17),4,6(10),11,18(22),23-hexaen-3-one;hydrochloride
Molecular Weight	389.83
Molecular Formula	C20H19NO5·HCl
Canonical SMILES	CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3.Cl
InChI	InChI=1S/C20H19NO5.ClH/c1-21-5-4-13-7-18-19(25-10-24-18)8-14(13)16(22)6-12-2-3-17-20(15(12)9-21)26-11-23-17;/h2-3,7-8H,4-6,9-11H2,1H3;1H
InChI Key	NWNVDSJZGYDVQW-UHFFFAOYSA-N
Purity	98%+ (HPLC)
Storage	Store in dry, low temperature, sealed, 2-8 °C.
Complexity	542
Exact Mass	389.1030004
Heavy Atom Count	27
Monoisotopic Mass	389.1030004
Topological Polar Surface Area	57.2Ų

Custom Q&A

What is the chemical formula of Protopine hydrochloride?

The chemical formula of Protopine hydrochloride is C20H20ClNO5.

What is the molecular weight of Protopine hydrochloride?

The molecular weight of Protopine hydrochloride is 389.83.

What are some synonyms for Protopine hydrochloride?

Some synonyms for Protopine hydrochloride include PROTOPINE HCL, MACLEYINE, and FUMARINE.

In what temperature should Protopine hydrochloride be stored?

Protopine hydrochloride should be stored at 2-8°C.

Is Protopine hydrochloride soluble in common solvents?

Yes, Protopine hydrochloride is soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.

How is Protopine hydrochloride used in the calibration curve preparation?

Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry.

What biological activities are associated with Protopine?

Protopine has diverse biological activities, including inhibiting platelet aggregation, inhibiting the growth of H. pylori, reducing growth of prostate cancer cells, and increasing latency to seizures in a mouse model.

How is Protopine metabolized in the body?

Protopine is metabolized by demethylenation in the presence of cytochrome enzymes, specifically cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).

What are some of the safety hazards associated with Protopine hydrochloride?

Protopine hydrochloride is classified as Hazardous Substances Data, with risk statements and safety statements indicating potential toxicity and precautions for handling.

What bioactivities does Protopine possess?

Protopine possesses anti-parasitic, antimicrobial, anti-inflammatory properties, it mediates mitotic arrest, and elicits anti-invasive effects in breast cancer tumor progression.

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