Pseudocoptisine chloride

Catalog Number	ACM30044781
CAS Number	30044-78-1
Molecular Weight	355.8
InChI	InChI=1S/C19H14NO4.ClH/c1-2-20-8-13-6-18-17(22-9-23-18)5-12(13)3-15(20)14-7-19-16(4-11(1)14)21-10-24-19;/h3-8H,1-2,9-10H2;1H/q+1;/p-1
InChI Key	QBOVLUUBUAZWIN-UHFFFAOYSA-M
Purity	95%+
Complexity	502
Covalently-Bonded Unit Count	2
Defined Atom Stereocenter Count	0
Exact Mass	355.0611356
Heavy Atom Count	25
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Monoisotopic Mass	355.0611356
PhysicalState	Powder
Rotatable Bond Count	0
Topological Polar Surface Area	40.8 Ų

Custom Q&A

What is the chemical formula of Pseudocoptisine chloride?

The chemical formula of Pseudocoptisine chloride is C19H14ClNO4.

What is the molecular weight of Pseudocoptisine chloride?

The molecular weight of Pseudocoptisine chloride is 355.77 g/mol.

Where can Pseudocoptisine chloride be stored?

Pseudocoptisine chloride can be stored at -20°C.

What is the biological activity of Pseudocoptisine chloride?

Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity and has anti-inflammatory and anti-amnestic effects.

How does Pseudocoptisine chloride inhibit NO production in RAW264.7 cells?

Pseudocoptisine chloride dose-dependently inhibits LPS-induced NO production in RAW264.7 cells.

What are the effects of Pseudocoptisine chloride on the production of TNF-α and IL-6 in RAW264.7 cells?

Pseudocoptisine chloride significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions in RAW264.7 cells.

How does Pseudocoptisine chloride reduce levels of pro-inflammatory mediators in RAW264.7 cells?

Pseudocoptisine chloride reduces levels of pro-inflammatory mediators by inhibiting NF-kappaB activation through the suppression of ERK and p38 phosphorylation in RAW264.7 cells.

What are the in vivo effects of Pseudocoptisine on learning and memory impairments in mice?

Pseudocoptisine significantly reverses cognitive impairments induced by scopolamine in mice by passive avoidance test.

What is the IC50 value of Pseudocoptisine chloride for inhibiting AChE activity?

The IC50 value of Pseudocoptisine chloride for inhibiting AChE activity is 12.8 μM.

What is the source of Pseudocoptisine chloride?

Pseudocoptisine chloride is a quaternary alkaloid with a benzylisoquinoline skeleton that is isolated from Corydalis Tuber.

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