Ritonavir

Catalog Number	ACM155213675-2
CAS Number	155213-67-5
Structure
Synonyms	Norvir
IUPAC Name	1,3-Thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
Molecular Weight	720.94
Molecular Formula	C37H48N6O5S2
Canonical SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChI	InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChI Key	NCDNCNXCDXHOMX-XGKFQTDJSA-N
Purity	98%+
Storage	Store in dry, low temperature, sealed, 2-8 °C.
Complexity	1040
Exact Mass	720.31276100
Heavy Atom Count	50
Isomeric SMILES	CC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC2=CC=CC=C2)C[C@@H]([C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
Monoisotopic Mass	720.31276100
Topological Polar Surface Area	202Ų

Custom Q&A

What is the chemical formula of Ritonavir?

The chemical formula of Ritonavir is C37H48N6O5S2.

What is the solubility of Ritonavir in DMSO?

Ritonavir is soluble in DMSO at a concentration of 10mg/mL (clear solution, warmed).

What is the primary use of Ritonavir?

Ritonavir is primarily used in combination with other antiretroviral agents for the treatment of HIV-1-infected patients.

How does Ritonavir work in the treatment of HIV?

Ritonavir is an inhibitor of HIV protease, which is critical in processing a propeptide into gene products, resulting in the release of non-infectious immature virus particles.

What is the brand name of Ritonavir?

The brand name of Ritonavir is Norvir.

What are some common side effects associated with full doses of Ritonavir?

Nausea, vomiting, diarrhea, and fatigue are common side effects associated with full doses of Ritonavir.

What is the role of Ritonavir in the treatment of chronic hepatitis C virus genotype 1 infection?

Ritonavir is used in combination with dasabuvir sodium hydrate, ombitasvir, and paritaprevir (under the trade name Viekira Pak) for the treatment of chronic hepatitis C virus genotype 1 infection.

What is the mechanism of action of Ritonavir when used as a booster drug?

Ritonavir acts as a strong CYP3A inhibitor and a P-glycoprotein inhibitor, increasing the exposure of concomitantly administered medications to effective concentrations.

How is Ritonavir metabolized in the body?

Ritonavir is extensively metabolized in the liver primarily by cytochrome P450 isoenzymes CYP3A4, with about 86% of the dose eliminated through the feces.

What is the stability of Ritonavir as supplied?

Ritonavir is stable for 1 year from the date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

※ Please kindly note that our products are for research use only.