Rotundine

Catalog Number	ACM483147-2
CAS Number	483-14-7
Description	Alkaloid found in Corydalis yanhusuo root, which is an herbal pain remedy
Synonyms	L-TetrahydropalmatineO,O-Dimethyl-N-demethyl-cyclanolineGindarine(13aS)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a, g]quinolizineL-THP
Molecular Weight	355.43 g/mol
Molecular Formula	C21H25NO4
Canonical SMILES	COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
Storage	store at 10℃-25℃
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939791000 - UK: 2939490000 - China: 2939799091
MDL Number	MFCD00214191

Custom Q&A

What is the molecular formula of Rotundine?

The molecular formula of Rotundine is C21H25NO4.

What is the melting point of Rotundine?

The melting point of Rotundine is 140-1°C.

In which plants is the isoquinoline alkaloid Rotundine found?

Rotundine is found in plants of the Corydalis genus (Yan Hu Suo) and Stephania rotunda (Qian Jin Teng).

What are some of the therapeutic effects of Rotundine?

Rotundine exhibits analgesic, antinociceptive, anxiolytic, antidepressant, and anti-parasitic activities.

When was Rotundine first discovered and isolated?

Rotundine was first discovered by Zhao Chenggu and isolated in 1965 from the resolution of DL-THP.

What are some of the uses of Rotundine in clinical practice?

Rotundine is used as an analgesic and sedative for treating pain, insomnia, cough, and gastrointestinal disorders.

What is the pharmacological mechanism of Rotundine on the central nervous system?

Rotundine acts as a central dopamine receptor blocker, inhibiting the transmission of peripheral pain information by blocking specific receptors.

How does Rotundine affect the cardio-cerebrovascular system?

Rotundine has inhibitory effects on cerebral and myocardial ischemia, lowers blood pressure, and has anti-inflammatory and anti-apoptotic effects.

What are some reported side effects of Rotundine?

Side effects of Rotundine may include drowsiness, dizziness, fatigue, and nausea.

How is Rotundine typically administered in clinical practice?

Rotundine can be administered orally and begins to take effect within 10-30 minutes, with effects lasting 2-5 hours.

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