Tetrahydropalmatine

Catalog Number	ACM483147
CAS Number	483-14-7
Structure
Synonyms	Rotundine
Molecular Weight	355.4
InChI	InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1
InChI Key	AEQDJSLRWYMAQI-KRWDZBQOSA-N
Melting Point	141-143 °C
Purity	98%+
Complexity	475
Covalently-Bonded Unit Count	1
Defined Atom Stereocenter Count	1
Exact Mass	355.17835828
Heavy Atom Count	26
Hydrogen Bond Acceptor Count	5
Hydrogen Bond Donor Count	0
Isomeric SMILES	COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
Monoisotopic Mass	355.17835828
PhysicalState	Solid
Rotatable Bond Count	4
Topological Polar Surface Area	40.2 Ų

Custom Q&A

What is the molecular formula of Tetrahydropalmatine?

The molecular formula of Tetrahydropalmatine is C21H25NO4.

What is the appearance of Tetrahydropalmatine?

Tetrahydropalmatine appears as white to pale yellow solid.

How is Tetrahydropalmatine used in preparation of other compounds?

Tetrahydropalmatine can be prepared from the total bases of tetrahydroxy berberine and can be used to prepare palmatine.

What are the uses of palmatine, which can be prepared from Tetrahydropalmatine?

Palmatine has a broad-spectrum antibacterial effect, treats gynecological inflammation, bacillary dysentery, and enhances relaxation of norepinephrine smooth muscle.

What is the main active substance of the Chinese herb corydalis?

The main active substance of the Chinese herb corydalis is DL-Tetrahydropalmatine.

How does Tetrahydropalmatine act in inhibiting an epileptic attack in rats?

Tetrahydropalmatine acts through the inhibition of amygdaloid release of dopamine in rats to inhibit an epileptic attack.

What are the chemical properties of Tetrahydropalmatine?

The melting point of Tetrahydropalmatine is 155℃, and it is slightly soluble in chloroform and methanol.

What effect does Picrotoxin treatment have on rats, and how does Tetrahydropalmatine counteract it?

Picrotoxin treatment increases certain activities in rats, and Tetrahydropalmatine decreases those activities. Tetrahydropalmatine pretreatment attenuates Picrotoxin-induced enhancement in certain activities.

What is the mechanism of action for Tetrahydropalmatine in inducing hypotension and bradycardia in rats?

Tetrahydropalmatine induces hypotension and bradycardia in rats through the antagonism of the striatal dopamine D2 receptor.

What is the synthesis pathway for Tetrahydropalmatine, starting from berberine hydrochloride?

Berberine hydrochloride is ring-opened under specific conditions to obtain desmethylene berberine hydrochloride, which is further methyl etherified to obtain palmatine hydrochloride, and then racemized under specific conditions to obtain Tetrahydropalmatine.

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