Vinflunine

Catalog Number	ACM162652951
CAS Number	162652-95-1
Structure
Description	Vinflunine is an antitumor agent that inhibits the mitochondrial membrane potential, resulting in the breakdown of intracellular ATP and cell death. Vinflunine has been shown to be effective against a number of carcinoma cell lines, including those from solid tumours (e.g., breast cancer) and those from blood cells (e.g., leukemia). Vinflunine has also been shown to be effective against angiogenic processes in vitro assays and in vivo trials. Vinflunine is active against natural compounds such as p-hydroxybenzoic acid, which are involved in the production of collagen and other proteins essential for tumor growth. In addition, vinflunine has been shown to cause significant cytotoxicity against tumors in vivo.
Canonical SMILES	CC[C@@]12C=CCN3[C@H]1[C@]4(CC3)[C@@H]([C@](C2OC(=O)C)(C(=O)OC)O)N(C5=CC(=C(C=C45)[C@]6(CC7CC(CN(C7)CC8=C6NC9=CC=CC=C89)C(C)(F)F)C(=O)OC)OC)C
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939791000 - UK: 2939790000 - China: 2939799091
MDL Number	MFCD00938122

Custom Q&A

What is the chemical formula for Vinflunine?

The chemical formula for Vinflunine is C45H54F2N4O8.

How is Vinflunine synthesized?

Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF5) and in the presence of a chlorinated solvent like CHCl3 or CCl4.

What is the brand name of Vinflunine?

The brand name of Vinflunine is Javlor.

What is the clinical use of Vinflunine?

Vinflunine is used as an antineoplastic agent for the treatment of advanced or metastatic bladder cancer.

How is Vinflunine metabolized in the body?

Vinflunine is metabolized by the cytochrome CYP3A4 isoenzyme, with the active metabolite 4-O-deacetylvinflunine (DVFL) being formed by multiple esterases.

What is the originator of Vinflunine?

Vinflunine was originated by Pierre Fabre in France.

What is the density of Vinflunine?

The density of Vinflunine is predicted to be 1.39±0.1 g/cm3.

What drug interactions should be avoided when taking Vinflunine?

Potentially hazardous drug interactions include those with antibacterials, antidepressants, antifungals, antimalarials, antipsychotics, antivirals, and grapefruit juice.

How is Vinflunine excreted from the body?

Vinflunine is excreted via the faeces (about two-thirds) and the urine (about one-third).

What is the recommended use of Vinflunine according to the European Medicines Agency (EMEA)?

Vinflunine is approved by the EMEA for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen.

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