Xanthoxoline

Catalog Number	ACM17014436
CAS Number	17014-43-6
Structure
Description	Xanthoxoline is an acidic chemical substance. It has been shown to have anti-cancer properties in vivo in animal models and cell cultures. Xanthoxoline inhibits the growth of leukemia cells by binding to DNA, preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Xanthoxoline also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.br>br>
Molecular Weight	271.27 g/mol
Molecular Formula	C15H13NO4
Canonical SMILES	COC1=C(C(=C2C(=C1)NC3=CC=CC=C3C2=O)O)OC

Custom Q&A

What is the chemical formula of xanthoxoline?

The chemical formula of xanthoxoline is C15H13NO4.

What is the molecular weight of xanthoxoline?

The molecular weight of xanthoxoline is 271.27.

What is the melting point of xanthoxoline?

The melting point of xanthoxoline is 256-257°C.

What is the predicted boiling point of xanthoxoline?

The predicted boiling point of xanthoxoline is 476.9±45.0°C.

How does xanthoxoline form pale yellow crystals?

Xanthoxoline is isolated from the leaves of Evodia xanthoxyloides.

What are the two melting points observed for xanthoxoline?

Xanthoxoline exhibits two melting points with intermediate solidification.

What is formed when xanthoxoline is oxidized with concentrated HNO3?

Oxidation with concentrated HNO3 produces 1:4-dihydro-4-oxo-3-quinoline carboxylic acid.

How is Melicopidine produced from xanthoxoline?

Treatment with methyl iodide in the presence of potassium carbonate gives Melicopidine.

Where can xanthoxoline be found naturally?

Xanthoxoline is isolated from the leaves of Evodia xanthoxyloides.

How was xanthoxoline studied according to the reference?

Xanthoxoline was studied by Hughes, Neill, Ritchie in Austral. J. Sci. Res., SA, 401 (1952).

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