Yohimbine hydrochloride

Catalog Number	ACM65190-2
CAS Number	65-19-0
Description	Yohimbine hydrochloride is a chemical compound that is classified as an alpha-2 adrenergic receptor antagonist. It has been shown to have high potency in vivo and in vitro for the α-7 nicotinic acetylcholine receptor. Yohimbine hydrochloride has been used in the treatment of erectile dysfunction and hypertension, with efficacy demonstrated in human serum, papillary muscle, locomotor activity, and dopamine release experiments.
Synonyms	17alpha-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride
IUPAC Name	Methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride
Molecular Weight	390.9 g/mol
Molecular Formula	C21H26N2O3·HCl
Canonical SMILES	C(OC)(=O)[C@@H]1[C@]2(C[C@]3(C4=C(C=5C(N4)=CC=CC5)CCN3C[C@@]2(CC[C@@H]1O)[H])[H])[H].Cl
InChI	InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1
InChI Key	PIPZGJSEDRMUAW-VJDCAHTMSA-N
Melting Point	288-290 °C (dec.)(lit.)
Purity	98%
Appearance	White powder
Storage	store at 10℃-25℃, protect from light
Complexity	555
Covalently-Bonded Unit Count	2
Defined Atom Stereocenter Count	5
Exact Mass	390.1710204
Harmonized Tariff Code	Switzerland: 29397900 - USA: 2939790000 - Slovakia: 2939799090 - UK: 2939799090 - China: 2939799099
Heavy Atom Count	27
Hydrogen Bond Acceptor Count	4
Hydrogen Bond Donor Count	3
Isomeric SMILES	COC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl
MDL Number	MFCD00012674
Monoisotopic Mass	390.1710204
PhysicalState	Powder
Rotatable Bond Count	2
Topological Polar Surface Area	65.6 Ų

Custom Q&A

What is the chemical name of yohimbine hydrochloride?

The chemical name of yohimbine hydrochloride is 17-HYDROXYYOHIMBAN-16-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE.

What is the CAS number of yohimbine hydrochloride?

The CAS number of yohimbine hydrochloride is 65-19-0.

What is the molecular formula of yohimbine hydrochloride?

The molecular formula of yohimbine hydrochloride is C21H27ClN2O3.

What are the synonyms of yohimbine hydrochloride?

The synonyms of yohimbine hydrochloride include YOHIMBE HCL, YOHIMBINE HCL, YOHIMBINE HYDROCHLORIDE, and QUERBRACHINE.

What is the melting point of yohimbine hydrochloride?

The melting point of yohimbine hydrochloride is 288-290 °C (dec.).

What are some of the side effects associated with yohimbine hydrochloride?

Some side effects of yohimbine hydrochloride include high blood pressure, increased heart rate, headache, anxiety, dizziness, nausea, vomiting, tremors, and sleeplessness.

What is the mechanism of action of yohimbine hydrochloride?

Yohimbine hydrochloride is a pre-synaptic alpha 2-adrenergic blocking agent that may increase sympathetic drive and norepinephrine release, leading to its beneficial effect in erectile ability.

How does yohimbine hydrochloride affect blood pressure?

Yohimbine hydrochloride may increase blood pressure by stimulating sympathetic nervous outflow, particularly in patients with increased basal sympathetic outflow or those taking certain antidepressants.

What are the main uses of yohimbine hydrochloride?

Yohimbine hydrochloride is used as an alpha adrenergic blocker, mydriatic, and antidepressant in the treatment of neurological disorders and erectile dysfunction.

How is yohimbine hydrochloride stored?

Yohimbine hydrochloride should be stored in a dark place, under an inert atmosphere, at room temperature.

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